When too much is not enough: an unexpected role for interferon signaling in a mouse model of Down syndrome (Neuroscience 2026) - Sep 27, 2026 - Abstract #NANO07.06; Pres time: Nov 15, 2026; 09:15 AM - 09:30 AM; Location: WCC Rm 144; "JAK-STAT inhibition (baricitinib) and genetic copy number rescue of IFN-I receptor dosage (Dp162xIFNAR1) failed to improve, and in some cases exacerbated, these behavioral phenotypes...Together, our data reveal a physiologic "goldilocks zone" of IFN-I signaling that promotes healthy brain development in this DS mouse model. This raises the question of whether enhancement, rather than inhibition of IFN-I signaling, may be therapeutically beneficial for some neurodevelopmental disorders."
Preclinical • CNS Disorders • Mental Retardation
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S. R. ANDERSON1,2; P. CHIARANUNT3; A. V. MOLOFSKY4
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