Integrated multi-omics analysis identifies PI3K-Akt signaling as a candidate pathway in glufosinate-induced neurotoxicity. (PubMed, Neurotoxicology) - Sep 27, 2026 - "Quantitative PCR confirmed selected transcriptional changes related to cellular remodeling, while increased AKT phosphorylation together with a modest prolongation of the restricted mean seizure-free time following LY294002 treatment provided supportive evidence for the potential involvement of PI3K-Akt signaling. Collectively, this study provides a systems-level characterization of molecular responses to acute GLA exposure and highlights PI3K-Akt signaling as a candidate pathway for future mechanistic investigation."
Journal • CNS Disorders • Epilepsy
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Aihua Peng; Lili Chu; Shiyuan Tang; Tingyuan Zhou; Wen Ma; Xinjie Xiang; Xuxin Xie; Yu Cao
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