Immunotoxicological mechanism of a dual-targeted nanocomposite: Mitochondrial stress-driven cGAS-STING activation in lung cancer. (PubMed, Colloids Surf B Biointerfaces) - Oct 24, 2026 - "Notably, combination with the PD-1 inhibitor sintilimab produces synergistic antitumor efficacy without observable systemic toxicity. Collectively, FU@TPP/BSA@MnO/UA bridges mitochondrial disruption with innate immune activation, offering a promising dual-mechanism strategy for lung cancer treatment and checkpoint immunotherapy enhancement."
Journal • Lung Cancer • Metabolic Disorders • Oncology • Solid Tumor • BAX • BCL2 • CD8 • IFNG • IL1B • IL6 • STING • TNFA
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Chengshuang Wang; Chuanlong Guo; Fangyu Jiao; Fengshu Fei; Haofan Wang; Jun Xiao; Lin Long; Pengyu Xue; Shiyu Ma; Xiaochen Wu; Xinyue Feng
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