Network pharmacology-guided investigation of the anti-angiogenic mechanisms of Spatholobus suberectus Dunn stem in rheumatoid arthritis. (PubMed, J Ethnopharmacol) - Oct 25, 2026 - "SC effectively ameliorates RA progression by mitigating synovial inflammation and preventing structural joint damage. Its therapeutic efficacy is primarily driven by the suppression of pathological angiogenesis via the targeted dual-inhibition of the EGFR/PI3K/AKT/HIF-1α signaling axes."
Journal • Immunology • Inflammation • Inflammatory Arthritis • Musculoskeletal Pain • Rheumatoid Arthritis • Rheumatology • ER • HIF1A • IL1B • IL6 • PECAM1 • PIK3CB • STAT3 • TNFA
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Longwen Deng; Qingsong Li; Yang Liu; Yanming Huang; Yaohui Ye; Zhengxin Zhou
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