Semaglutide and Tirzepatide Suppress Hepatic Fatty Acid Uptake and Fatty Acid β-Oxidation in High-Fat Diet-Induced Obesity Mice. (PubMed, J Proteome Res) - Oct 28, 2026 - "These findings suggest a substrate limitation over enhanced β-oxidation or broad lipogenesis-suppression, suggesting GLP-1 receptor activation is sufficient for the core liver response and GIP co-agonism mainly augments extrahepatic effects. From a One Health proteomics perspective, CD36/CPT1A anchored targeted proteomic signature provides a mechanistically informed benchmark for evaluating novel GLP-1 and non-GLP-1 investigational therapeutics."
Journal • Preclinical • Genetic Disorders • Hepatology • Metabolic Disorders • Obesity • ACSS2 • CD36 • CPT1A • FASN • SCARB1
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Dhavalkumar Patel; Heba Ewida; Mahmoud Salama Ahmed; Md Tareq Aziz; Prasanth K Chelikani; Syed Tareq; Ulrich Bickel
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