Design and initiation of an adaptive, randomized, controlled study of berubicin, a topoisomerase 2 poison that crosses the blood brain barrier (BBB), for the treatment of recurrent glioblastoma multiforme (GBM) after first-line therapy.

doxorubicin hydrochloride - Generic mfg.

berubicin (RTA 744) - CNS Pharma, WPD Pharma

lomustine - Generic mfg.

Avastin (bevacizumab) - Roche

temozolomide - Generic mfg.

Sandra Silberman; Sigmund H. Hsu; Zena Muzyczenko; Donald Picker; Waldemar Priebe

Apr 28, 2022