A codon-optimised human sequence of human MC4R regulates cAMP levels and normalise weight in Mc4r mutant obese males and females when delivered with as a self-complementary AAV9 (scAAV9) with an intracerebroventricular delivery.

AXV-201 - Axovia Therap

https://www.sciencedirect.com/science/article/pii/S1525001625003028

Victor Hernandez 1; Rakhi Kesavan Nair Rema 2; Elisa Cuevas 3; Gabriela Carreno 3; Marian Seda; Phil Beales 4; Jeshmi Jeyabalan Srikaran 2; Natalie Northcott 5

Apr 28, 2025