An Ultra-Fast UPLC-MS/MS Method for Quantifying Ivosidenib: Application to Assessment of Metabolic Stability in Human Liver Microsomes. (PubMed, Arch Pharm (Weinheim)) - Sep 16, 2026 - "A straightforward isocratic mobile phase system with a stationary phase (C8 column) efficiently separated IVB and baricitinib (BCB as internal standard) in an ultra-fast 1-min run at 0.4 ml/min flow rate. The in vitro half-life (t1/2) of IVB was approximately 44.89 min, with an intrinsic clearance (Clint) of 18.06 ml/min/kg. In silico analysis suggests that IVB derivatives with modifications to the 5-fluoro-3-pyridine group (75% at C21) and the 4-cyano-2-pyridine group (23% at C36) may exhibit varying metabolic stability, warranting further experimental validation."
Journal • Oncology • IDH1
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Adnan A Kadi; Ali S Abdelhameed; Haitham Alrabiah; Mohamed W Attwa
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