Design, synthesis and biological evaluation of N-pyridinyl ureidobenzenesulfonates and their hydrochloride salts as novel water-soluble dihydroorotate dehydrogenase inhibitors inducing differentiation of acute myeloid leukemia cells.

brequinar (DUP 785) - BMS, Clear Creek Bio

http://www.ncbi.nlm.nih.gov/pubmed/40734665

Atziri Corin Chavez Alvarez; Chahrazed Bouzriba; Geneviève Hamel-Côté; Sébastien Fortin; Vincent Ouellette

Jul 30, 2025