Filgotinib inhibits METTL3-mediated m6A of EIF3A by targeting ERG-TBP to suppress PDAC progression JAK-STAT3-independently.

Jyseleca (filgotinib) - Gilead

Jakafi (ruxolitinib) - Incyte

http://www.ncbi.nlm.nih.gov/pubmed/41922492

Chaolei Zhang; Chengjie Xu; Jianghao Ren; Kexiong Qiao; Liangjing Zhou; Liping Cao; Shengnan Jia; Xiaofan Pu; Zongrong Chen

Apr 2, 2026