Sestrin3 confers resistance to recombinant human arginase in small cell lung cancer by activating Akt/mTOR/ASS1 axis.

MK-2206 - Merck (MSD)

sirolimus - Generic mfg.

pegylated recombinant human arginase (BCT-100) - BCT international

http://www.ncbi.nlm.nih.gov/pubmed/41460862

Binxiong Chen; Hanchao Gao; Shi Xu; Weishan Li; Yueming Liu; Zhongqiang Zhang; Zizhe Lin

Dec 29, 2025