Nociceptin Receptor-Related Agonists as Safe and Non-addictive Analgesics. (PubMed, Drugs) - May 20, 2023 - "Moreover, mixed NOP/MOP receptor partial agonists (e.g., BU08028, BU10038, and AT-121) display potent analgesic effects when administered intrathecally or systemically, without eliciting adverse effects, such as respiratory depression, itch behavior, and signs of abuse liability. More importantly, cebranopadol, a mixed NOP/opioid receptor agonist with full efficacy at NOP and MOP receptors, produces robust analgesic efficacy with reduced adverse effects, conferring promising outcomes in clinical studies. A balanced coactivation of NOP and MOP receptors is a strategy that warrants further exploration and refinement for the development of novel analgesics with a safer and effective profile."
Journal • Review • Addiction (Opioid and Alcohol) • CNS Disorders • Depression • Pain • Psychiatry
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