Multimechanistic Single-Entity Combinations for Chronic Pain Control: A Narrative Review. (PubMed, Cureus) - Jul 23, 2022 - "Atypical opioids such as tramadol, tapentadol, and cebranopadol combine two complementary mechanisms of action into a single molecule, creating novel analgesic agents...Patients have been successfully rotated from one of these agents to another. All three agents show promise in the treatment of cancer and non-cancer pain and their unique formulation in a single molecule reduces the pill burden."
Journal • Review • Oncology • Pain
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