Emerging technologies in acute pain management. (PubMed, Pain Manag) - Feb 14, 2026 - "Pharmacological innovations such as sublingual sufentanil, liposomal bupivacaine, Nav 1.8 inhibitors, cebranopadol, and co-crystals of tramadol-celecoxib also show promise. Novel delivery systems - oral patient-controlled analgesics devices, transdermal iontophoretic fentanyl, and bioresorbable nerve stimulators - further enhance individualized pain control. Technological advancements are expanding the toolkit for acute pain management, offering non-opioid, patient-centered, and precision-based alternatives. However, further large-scale and longitudinal studies are required to validate their efficacy, safety, and cost-effectiveness across diverse patient populations and clinical settings." Journal • Review • Addiction (Opioid and Alcohol) • Pain
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Benjamin Rapsas; Bijan Moazezi; Haley Warzecha; Kelsey Sawyer; Vendhan Ramanujam; Yash Shah
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