Discovery of highly potent and efficacious Bromodomain and Extra-terminal (BET) degraders with activity against acute myeloid leukemia and triple-negative breast cancer.

ARV-825 - Arvinas

SHP099 - Novartis

http://www.ncbi.nlm.nih.gov/pubmed/42715871

Dandan He; Fei Jiang; Huili Li; Jiandong Huang; Ling Tao; Milin Tao; Qian Liang; Quan Sun; Wei Liu; Wenbao Zhang; Xiangchun Shen; Xianggui Chen; Xingmei Chen; Xueyuan Luo; Yan Chen; Yuanju Peng

Sep 10, 2026