Effect of Pre-Incisional Intravenous Paracetamol-Ibuprofen on Post-Laparoscopic Shoulder Pain After Laparoscopic Cholecystectomy: A Double-Blind Randomised Controlled Trial. (PubMed, J Clin Med) - Sep 27, 2026 - "Background: This study was designed to evaluate the analgesic effect of pre-incisional intravenous administration of a fixed-dose combination of paracetamol and ibuprofen (Maxigesic®; Kyungbo Pharmaceutical, Seoul, Republic of Korea), with particular attention to post-laparoscopic shoulder pain (PLSP), in patients undergoing laparoscopic cholecystectomy (LC)...There were no significant differences between the two groups in postoperative nausea and vomiting. Pre-incisional intravenous administration of a fixed-dose paracetamol-ibuprofen combination was associated with a lower incidence of PLSP and a lower proportion of patients requiring rescue analgesia in patients undergoing LC, although shoulder-pain severity among patients who developed PLSP was not significantly reduced."
Journal • Anesthesia • Musculoskeletal Pain • Pain
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Seong-Hyop Kim; Seung-Wan Hong
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