Drugs in Development to Manage Acute Pain. (PubMed, Drugs) - Nov 20, 2024 - "These agents include VX-548 (Suzetrigine), Cebranopadol, AAT-076, Combogesic intravenous (IV), sublingual ketamine, XG004 (naproxen/pregabalin conjugate), and HTX-011 (Zynrelef). We analyze the pharmacodynamics, pharmacokinetics, development status, and clinical implications of these drugs, emphasizing the importance of finding an agent that provides both a strong safety profile and effective relief from acute pain. Our findings show promise but also highlight the need for further large-scale research to allow these drugs to be utilized in a clinical context for patients experiencing acute pain."
Journal • Review • Pain
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Alina Razak; Brian Oliver; Catherine Devitt; Grace Park; Sergio D Bergese; Sun Mei Liu
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