Case Report: Local injection of an IL-17 inhibitor successfully treats Acrodermatitis continua of Hallopeau and avoids immune shift. (PubMed, Front Immunol) - Jun 26, 2026 - "A 13-year-old female patient with ACH showed poor responses to systemic acitretin, upadacitinib, and topical calcipotriol/betamethasone. After switching to systemic Xeligekimab, her hand and foot pustules improved rapidly, but eczematous eruptions appeared...The Palmoplantar Pustulosis Area and Severity Index (PPPASI), Dermatology Life Quality Index (DLQI), and Nail Psoriasis Severity Index (NAPSI) all decreased substantially, and no immune drift recurred. This case suggests that local injection of an IL-17 inhibitor may effectively control skin lesions while potentially avoiding systemic immune imbalance, offering a preliminary novel treatment approach for refractory ACH that requires further validation."
Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Psoriasis • Pustular Psoriasis • IL17A
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Chen Li; Shiying Li; Tao Guo; Yali Li; Yuhan Chen; Yuning Zhang
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