Restoring the Sense of Smell: A Systematic Review and Meta-Analysis of Biologic Therapies for Chronic Rhinosinusitis with Nasal Polyps. (PubMed, Curr Allergy Asthma Rep) - Nov 20, 2025 - "In single RCTs, benralizumab showed large effect (1.03, 0.55-1.51), tezepelumab (0.56, 0.46-0.67), telikibart (0.35, 0.11-0.59), and omalizumab (0.27, 0.15-0.40) yielded modest but significant improvements. Mepolizumab showed no effect (0.1330 (95% CI -0.2490-0.5150)...The cohort studies supported the findings (SMD = 1.20, 95% CI = 0.99-1.42), though most data were derived from studies of dupilumab. Overall, biologics substantially improve psychophysically measured olfactory function in CRSwNP. Future head-to-head trials are warranted to delineate comparative efficacy of smell recovery."
Clinical • Journal • Retrospective data • Review • Chronic Rhinosinusitis With Nasal Polyps • Immunology • Inflammation • Nasal Polyps • Otorhinolaryngology • Respiratory Diseases • Sinusitis
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Anne-Sophie Homøe; Christian K Pedersen; Christian Von Buchwald; Jens Even Tidemandsen; Kasper Aanæs; Marie Høxbro; Simon Høj; Vibeke Backer
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