A Time-Resolved FRET Activity Assay to Distinguish Enzymatic Inhibition from PROTAC-Mediated Degradation of SARS-CoV-2 Mpro.

Paxlovid (nirmatrelvir/ritonavir) - Pfizer

http://www.ncbi.nlm.nih.gov/pubmed/42631572

Andreas Heine; Anke-Dorothee Werner; Christopher Veeck; Jasmin Jekkel; Lennart Laube; Luna Clara Schmacke; Stephan Becker; Torsten Steinmetzer; Wibke Diederich

Aug 23, 2026