Plasma concentrations of nirmatrelvir and molnupiravir required for inhibition of SARS-CoV-2 replication differ between rhesus macaques and humans.

Paxlovid (nirmatrelvir/ritonavir) - Pfizer

Lagevrio (molnupiravir) - Ridgeback Biotherap, Merck (MSD)

http://www.ncbi.nlm.nih.gov/pubmed/42554640

Joshua T Schiffer; Katherine Owens; Shadisadat Esmaeili; Ugo Avila-Ponce de León

Aug 6, 2026