Design, synthesis, and X-ray structural studies of potent SARS-CoV-2 Mpro inhibitors containing tetrahydroisoquinoline-3-carboxamides as P2 ligands.

Paxlovid (nirmatrelvir/ritonavir) - Pfizer

http://www.ncbi.nlm.nih.gov/pubmed/42376329

Andrew D Mesecar; Arun K Ghosh; Ashish Sharma; Emma K Lendy; Hiroaki Mitsuya; Nobuyo Higashi-Kuwata; Satyanarayana Iddum; Shin-Ichiro Hattori; Sydney N Bogan; Uttara Jayashankar

Jul 1, 2026