UBE2S promotes gastric cancer progression through RACGAP1 stabilization associated with K292-dependent K63-linked ubiquitination. (PubMed, Cancer Biol Ther) - Oct 9, 2026 - "Pharmacological JNK inhibition with SP600125 suppressed RACGAP1-mediated JNK/c-Jun reactivation and clonogenic rescue. Our findings support a model in which UBE2S promotes GC progression by stabilizing RACGAP1 in association with K292-dependent K63-linked ubiquitination, providing a mechanistic basis for further preclinical investigation of the UBE2S/RACGAP1/JNK/c-Jun axis."
Journal • Gastric Cancer • Oncology • Solid Tumor • Targeted Protein Degradation • RACGAP1
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Hefei Cheng; Qirun Cheng; Ziqi Sui; Ziqing Zhou
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