The crosstalk between alternative splicing and histone ubiquitination modulates fast chemical reprogramming to pluripotency. (PubMed, Stem Cell Reports) - Sep 25, 2026 - "Pharmacological inhibition of inflammatory pathway using Amlexanox and BMS-345541 could further improve FCR efficiency. Collectively, our results highlight the essential role of AS in FCR and suggest that the crosstalk between AS and histone ubiquitination mediated by PTBP3-SCMH1 axis can be harnessed for modulating cell fates. These studies will help to better understand the fascinating question of how small molecules alone can rapidly induce pluripotency and provide new approaches for regeneration and rejuvenation."
Journal • Targeted Protein Degradation • SCMH1
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Dylan Zhu; Guo Chen; Qian Deng; Saiyong Zhu; Xi Chen; Yixin Wang; Yueqing He; Yuhan Li
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