Investigation of the effect of formulated sodium lauryl sulfate on microenvironment-driven dissolution of repotrectinib immediate-release capsules. (PubMed, J Pharm Sci) - Sep 24, 2026 - "This mechanism provides a scientific basis for understanding dissolution behavior in highly surfactant-loaded formulations and explains the reduced sensitivity of conventional dissolution testing to moderate formulation changes. The findings provide important considerations for dissolution method development, interpretation of discriminating capability, and regulatory assessment of surfactant-containing oral drug products."
Journal • CNS Disorders • Psychiatry
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Angela Hu; Scott P Jennings; Zongyun Huang
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