Targeting Macrophage-Mediated Lymphatic Immunosuppression to Prevent Tumor Recurrence After Microwave Ablation. (PubMed, Adv Sci (Weinh)) - Sep 30, 2026 - "Accordingly, an albumin-based lipoprotein nanosystem co-encapsulating paclitaxel (PTX) and the CSF1R inhibitor BLZ945 (PTX/BLZ945@Alb-lip) was developed. Moreover, treatment promotes durable antitumor immune memory and protects cured mice against tumor rechallenge. These findings identify TDLNs as an important therapeutic site in post-ablation immunotherapy and provide a potential strategy to prevent tumor recurrence following ablation."
IO biomarker • Journal • Oncology • Solid Tumor • APOE
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Chengzhong Peng; Fengshan Jin; Huixiong Xu; Liping Sun; Qiuyan Li; Shaoyue Li; Shuo Liu; Weichen Xu; Weifan Hao; Weiwei Ren; Wenwen Yue; Xiaodong Hou; Xiaowan Bo; Xuexia Shan; Yuting Shen
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