Anti-proliferative and anti-inflammatory potential of 2-chloro-3-((4-hydroxyphenyl)amino)naphthalene-1,4-dione through targeting TNF-α/IL-8 and NF-κB signaling in HCT116 cancer cells: a comprehensive in silico docking and in vitro study. (PubMed, Biochem Biophys Rep) - Sep 26, 2026 - "Molecular docking analysis demonstrated that the tested compound favorably interacted with key amino acid residues within human NF-κB/p50, the p50/p65 NF-κB complex, and IKKβ, with binding patterns to the active sites comparable to those of the reference inhibitors, MLN120B and BMS-345541...Collectively, these findings suggest that compound 12 exerts anticancer activity through dual anti-inflammatory and pro-apoptotic mechanisms, possibly by modulating the NF-κB pathway. This compound may therefore represent a promising lead candidate for further drug development against CRC."
Journal • Preclinical • Colorectal Cancer • Oncology • Solid Tumor • CXCL8 • TNFA
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Kiattawee Choowongkomon; Panupong Mahalapbutr; Panyakorn Taweechat; Ratchanok Pingaew; Ronnakorn Leechaisit; Sakdiphong Punpai; Wanlaya Tanechpongtamb
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