Podophyllotoxin Derivatives in Oncology: Mechanistic Insights, Therapeutic Applications, and Future Directions. (PubMed, Mini Rev Med Chem) - Sep 21, 2026 - "Various derivatives of PTOX, including etoposide and teniposide, are well-established chemotherapeutics, although their use is largely hampered by systemic toxicity, low solubility, and drug resistance. Recent strategies involving the incorporation of PTOX into nanoparticles, hybrid molecules, and other bioactive systems have expanded its therapeutic potential by improving solubility, pharmacokinetics, and tumor selectivity. Overall, understanding structural modifications and molecular interactions of PTOX derivatives provides a strong foundation for the rational design of more potent and targeted anticancer agents."
Journal • Colorectal Cancer • Oncology • Solid Tumor • AMPK • CHEK2 • HIF1A • TWIST1
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Sakshi Soni; Sunny Rathee; Umesh K Patil
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