Opdivo (nivolumab) - Ono Pharmaceutical, BMS
Actemra IV (tocilizumab) - Roche, JW Pharma, Chugai Pharmaceutical
Clinical characteristics, treatment and prognosis of nivolumab induced cytokine release syndrome. (PubMed, Support Care Cancer) - Oct 2, 2026 - "Nivolumab-induced CRS can lead to multi-organ functional impairment and even be fatal. During the administration of nivolumab, the possibility of CRS should be taken into consideration. Glucocorticoids and tocilizumab are widely utilized as primary therapeutic approaches for the management of CRS in clinical practice. However, given the limited available evidence and inherent clinical confounders, the standardized and optimal treatment strategy for nivolumab-induced CRS remains undefined and requires further exploration." 
Journal • Retrospective data • Cardiovascular • CNS Disorders • Fatigue • Hepatology • Hypotension • Inflammation • Liver Failure • Oncology • Renal Disease • CRP • IL6
http://www.ncbi.nlm.nih.gov/pubmed/42821011
 
Chunjiang Wang; Liping Peng; Shaoli Zhao; Wei Sun
 
Oct 2, 2026
 
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