Computational identification and characterization of high-risk human KRAS nsSNPs: Impacting structure, ligand binding, and cancer prognosis. (PubMed, J Genet Eng Biotechnol) - Sep 17, 2026 - "Docking and simulation analyses showed that the Y71D and M72K nsSNPs reduced binding affinity and stability with ligand sotorasib (CID: 137278711) compared to wild-type KRAS, whereas both high-risk nsSNPs exhibited enhanced binding and stability with ligand adagrasib (CID: 138611145), indicating mutation-dependent ligand interactions. Cancer susceptibilities analyses indicated both Y71D and M72K may promote cancer prognosis. These results highlight Y71D and M72K as high-risk KRAS nsSNPs affecting structural stability, ligand interactions, and cancer prognosis, providing a framework for mutation-specific therapeutic strategies and supporting further experimental validation in precision oncology."
Journal • Oncology • Solid Tumor • KRAS
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Abu Zaffar Shibly; Afia Khandaker; Juthi Adhikari; Md Mainuddin Hossain; Md Zakiul Islam Zaki; Sabbir Ahmed
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