Ribes fasciculatum Leaf Water Extract Enhances Macrophage Immune Responses via TLR4-Mediated JNK and NF-κB Activation in RAW264.7 Cells. (PubMed, J Microbiol Biotechnol) - Sep 11, 2026 - "The immunostimulatory effects of RFL-DW20 were strongly inhibited by TAK-242, SP600125, and BAY 11-7082, suggesting the involvement of TLR4, JNK, and NF-κB signaling. Ethanol precipitation further enriched its NO-inducing activity. These findings suggest that RFL-DW20 activates macrophages through the TLR4/JNK/NF-κB signaling axis and may serve as a natural immune-stimulating material."
Journal • IL1B • IL6 • NFKBIA • PTGS2 • TLR4 • TNFA
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Bo Hee Seo; Gyeong Eun Im; Ha Eun Kim; Hyeok Jin Choi; Jenna Jung; Jeong Won Choi; Jin Boo Jeong; Kwan Been Park; Myung Suk Choi; Seon A Kim; So Jung Park
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