Kinase Inhibitor Screening Reveals Novel Regulators of Aqp2 Transcription (KIDNEY WEEK 2026) - Oct 2, 2026 - Abstract #TH-PO0033; Pres time: Oct 22, 2026; 10:00 AM - 12:00 PM; Location: Exhibit Hall A, Convention Center; "One of the identified hits is the JNK inhibitor, JNK-IN-8, which increased AQP2 abundance even in the absence of desmopressin. A similar effect was observed by a different JNK inhibitor, CC-930...Acquired nephrogenic diabetes insipidus ("vasopressin resistance") is generally associated with a failure of Aqp2 gene transcription. The finding that JNK inhibition increases Aqp2 gene transcription in the absence of vasopressin points out a possible novel therapeutic direction and a starting point for drug development to optimize therapeutic ratio."
Metabolic Disorders • ARG2 • ATF3 • TGFB1
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Adrian Rafael Murillo-de-Ozores; Lihe Chen; Mark A. Knepper
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