Isoform analysis of myosin pools suggests upregulated myosin 6 (MYH6) expression in prostates from surgical BPH as a candidate target for the development of smooth muscle and BPH-specific myosin inhibitors (DGU 2026) - Oct 15, 2026 - Abstract #V05-05; Pres time: Sep 16, 2026; 11:10 AM - 11:20 AM; Location: Room A; "Introduction: The introduction of the cardioselective myosin-7 (MYH7) inhibitor mavacamten for hypertrophic obstructive cardiomyopathy reflects an emerging interest in organ-specific myosin inhibitors... MYH6 is upregulated in surgical BPH and associated with reduced Q max , qualifying it as a candidate target in development of organ- or BPH-specific myosin inhibitors. Non-contractile myosin functions may contribute to bladder outlet obstruction, as exemplified by MYH7."
Benign Prostatic Hyperplasia • Cardiomyopathy • Genito-urinary Cancer • Hypertrophic Cardiomyopathy • Obstructive Hypertrophic Cardiomyopathy • Prostate Cancer • Solid Tumor • MYH7
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M. Brandstetter 1; P. Keller 1; Y. Xu 1; P. Weinhold 1; A. Tamalunas 1; C.G. Stief 1; M. Hennenberg 1
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