Evaluation of 18F-FPPA as a Positron Emission Tomography Radioligand for Imaging CSF1R in LPS-Induced Rat Model of Neuroinflammation. (PubMed, Mol Pharm) - Sep 8, 2026 - "A decreased uptake also was observed in cold 19F-FPPA, BLZ945, and PLX3397 blocking groups (P 0.05). The in vivo imaging and immunohistochemical results confirmed the specific uptake of 18F-FPPA by targeting CSF1R on microglia in inflamed tissues. Overall, our findings demonstrated that 18F-FPPA had great potential as a promising tracer for the imaging of neuroinflammatory diseases, while its unique binding profile also provides insights into CSF1R-targeted ligand development."
Journal • Preclinical • Gastrointestinal Disorder • Inflammation • CSF1R
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Cheng Wang; Dengfeng Cheng; He Zhang; Hongxing Su; Qingyu Lin; Rong Sheng; Zhenwei Wang; Zhequan Fu; Zhoumi Hu
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