Primary adrenal small cell neuroendocrine carcinoma in a patient with sarcoidosis and synchronous colon adenocarcinoma. (PubMed, JCEM Case Rep) - Oct 15, 2026 - "Cisplatin plus irinotecan induced a partial response; however, disease progression was observed. Second-line amrubicin therapy reduced tumor size; comprehensive genomic profiling revealed a tumor mutation-burden-high phenotype. This case highlights diagnostic challenges in the evaluation of lymphadenopathy in patients with sarcoidosis and synchronous malignancy, emphasizing the importance of pathological confirmation for guiding appropriate management."
Journal • Tumor mutational burden • Colon Adenocarcinoma • Colon Cancer • Colorectal Adenocarcinoma • Colorectal Cancer • Endocrine Cancer • Genitourinary Neuroendocrine Carcinoma • Immunology • Neuroendocrine Carcinoma • Oncology • Sarcoidosis • Solid Tumor • SYP • TMB
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Akio Miyamaoto; Asami Sano; Teppei Yamamoto; Tetsu Takeichi; Yukiko Kusama; Yutaka Nishii
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