Solving an enigma: the BMP-9/10 axis as a key regulator of pulmonary vascular resilience. (PubMed, Eur Respir J) - Sep 8, 2026 - "The clinical success of sotatercept, an activin signaling inhibitor with partial BMP-ligand trap properties, underscores the translational potential of therapeutically "retuning" this pathway rather than globally enhancing it. Understanding when BMP-9/10 signaling protects and when it becomes pathogenic will be crucial for designing next-generation interventions that stabilize, instead of destabilize, pulmonary vascular integrity."
Journal • Review • Cardiovascular • Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • ALK1 • ENG
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Christophe Guignabert; Marc Humbert
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