Integrative analysis of Alzheimer's disease molecular networks with circadian regulators for prioritization of drug repurposing candidates. (PubMed, J Alzheimers Dis) - Oct 14, 2026 - "Several drugs previously investigated in dementia-related clinical trials were recovered. Novel repositioning candidates, including PF-562271, MGCD-265, and BMS-777607, were identified, converging on focal adhesion kinase (FAK), PI3K-AKT, and receptor tyrosine kinase (RTK) signaling pathways enriched in AD-associated genes and implicated in circadian regulation and neuroinflammation.ConclusionsThis integrative analysis identifies mechanistically coherent repurposing candidates, associated with circadian and inflammatory pathways, supporting systems-based strategies for therapeutic prioritization in complex neurodegenerative diseases."
Journal • Alzheimer's Disease • CNS Disorders • Dementia • Inflammation • Sleep Disorder
|
|
Alexandros Zantis; Chiara Pallara; Elisa Uliassi; Xinzhong Li
|