Temporal dissection of hepatitis C virus and orthoflavivirus infections by continuous luminescence monitoring. (PubMed, J Virol) - Oct 13, 2026 - "Continuous monitoring also distinguished phase-specific antiviral activities, revealing distinct kinetic inhibition profiles for daclatasvir, acetylsalicylic acid, and interferon-α...Together, our study establishes continuous temporal monitoring as a general strategy for resolving dynamic virus-host interactions and for uncovering molecular events that remain obscured by conventional endpoint analyses.IMPORTANCEViral infection is a dynamic process in which entry, genome amplification, host-factor requirements, antiviral effects, and cellular responses occur on different timescales...We further showed that ATF6-mediated ER stress activation emerged later than early HCV infection and viral RNA amplification. Thus, continuous temporal monitoring provides a general strategy for resolving dynamic virus-host interactions by defining the temporal relationships among viral processes, pharmacological effects, and host responses that remain obscured by conventional endpoint..."
Journal • Dengue Fever • Hepatitis C • Infectious Disease • Inflammation • ATF6
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Alu Konno; Fumihiro Kato; Haruyo Aoyagi; Hideki Aizaki; Jie Liu; Kaho Matsumura; Kodama Watanabe; Koichi Watashi; Kwang Su Kim; Mami Matsuda; Mana Watanuki; Masahiko Ito; Masayoshi Fukasawa; Ryosuke Suzuki; Shigeru Tajima; Shingo Iwami; Takaji Wakita; Takanobu Kato; Takayuki Hishiki; Tetsuro Suzuki; Toru Takada; Xiaoyu Li; Yasumasa Iwatani
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