Generation of an Endogenous PDAC-Specific TCR Transgenic Mouse (AACRPanCa 2026) - Oct 15, 2026 - Abstract #B119; "Using orthotopically implanted KPCY (6694c2) tumors, we have demonstrated that a stabilized IL-21 variant (21h10) combined with the KRAS inhibitor MRTX1133 cured resistant PDAC through a CD4+ T cell–dependent, but CD8+ T cell–independent, mechanism...In: Proceedings of the AACR Conference on Pancreatic Cancer: New Frontiers in Biology and Therapeutic Development; 2026 Sep 25-28; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2026; 86(18_Suppl_2):Abstract nr B119."
Preclinical • Microsatellite Instability • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • Solid Tumor • CD4 • CD8 • IL21 • KRAS • MSI
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Chong Zuo; Li Qiang; Madeline Fitzgibbon; Stephanie K. Dougan; Michael L. Dougan
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