Immune and stromal features of durable complete response to radiation and dual immune checkpoint blockade in pancreatic cancer (AACRPanCa 2026) - Oct 15, 2026 - Abstract #B096; P2 | "We conducted a single-arm phase II trial (NCT04361162) combining nivolumab, ipilimumab and radiation therapy to treat patients with pre-treated metastatic MSS PDAC (n=30)...This may have implications for the design of future immunotherapy and vaccine strategies for PDAC.Citation Format:Sarah Kang, Milan Parikh, Leontios Pappas, Lynn Bi, Julie L. Koenig, Beow Y. Yeap, Nicole Carzo, Tarin M. Grillo, Islam Baiev, Olanike Asupoto, Ana Lako, Irena Gushterova, Thomas J. Carmona-LaSalle, Anna L K. Gonye, Emily M. Blaum, Jeffrey W. Clark, Colin D. Weekes, Jill N. Allen, Lawrence S. Blaszkowsky, David P. Ryan, James M. Cleary, Joseph D. Mancias, Benjamin L. Schlechter, Sarah E. Slater, Jennifer Y. Wo Y. Wo, Thomas A. Abrams, Steven M. Corsello, Joseph W. Franses, Marios Giannakis, Jeffrey A. Meyerhardt, Matthew B. Yurgelun, Christine Bolton, Hannah J. Roberts, Sofia von Fedak, Lorraine C. Drapek, Brian M. Wolpin, David T. Ting, Moshe Sade-Feldman, Theodore S. Hong,...
Checkpoint block • Checkpoint inhibition • Clinical • IO biomarker • Stroma • Oncology • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • Solid Tumor • ACKR1 • CCL3 • CD8 • CXCL10 • CXCL13 • CXCL9 • CXCR3 • GZMK • POSTN
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Sarah Kang; Milan Parikh; Leontios Pappas; Lynn Bi; Julie L. Koenig; Beow Y. Yeap; Nicole Carzo; Tarin M. Grillo; Islam Baiev; Olanike Asupoto; Ana Lako; Irena Gushterova; Thomas J. Carmona-LaSalle; Anna L K. Gonye; Emily M. Blaum; Jeffrey W. Clark; Colin D. Weekes; Jill N. Allen; Lawrence S. Blaszkowsky; David P. Ryan; James M. Cleary; Joseph D. Mancias; Benjamin L. Schlechter; Sarah E. Slater; Jennifer Y. Wo Y. Wo; Thomas A. Abrams; Steven M. Corsello; Joseph W. Franses; Marios Giannakis; Jeffrey A. Meyerhardt; Matthew B. Yurgelun; Christine Bolton; Hannah J. Roberts; Sofia von Fedak; Lorraine C. Drapek; Brian M. Wolpin; David T. Ting; Moshe Sade-Feldman; Theodore S. Hong; Nir Hacohen; Aparna Parikh; Arnav Mehta; Ryan J. Park
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