Brequinar Exerts Antiviral Effects Against Aquareovirus via Host Pyrimidine Metabolism Modulation. (PubMed, J Fish Dis) - Oct 11, 2026 - "In a 30-day rare minnow model, Brequinar reduced viral loads after an initial rise, suggesting its potential application in reducing viral burden in virus-infected broodstock. Collectively, Brequinar exerts anti-GCRV activity by interfering with pyrimidine metabolism via DHODH inhibition and shows potential as a host-targeted antiviral strategy, with possible application in reducing viral burden in high-value broodstock in aquaculture."
Journal • Hematological Disorders • Infectious Disease
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Linyi Liu; Liqun Lu; Sen Han; Weijun Wu
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