Functional antagonism of the S1P - S1PR1 signaling axis decreases trigeminocervical sensitization and migraine like neuronal activation in stress-induced rats. (Neuroscience 2026) - Sep 27, 2026 - Abstract #PSTR015.17 / Y7; Pres time: Nov 14, 2026; 01:00 PM - 05:00 PM; Location: WCC Halls A-C; "Functional S1PR1 antagonists, such as ozanimod, have shown efficacy in preclinical models of chronic pain...These data demonstrate that a functional S1PR1 antagonist attenuates dural-TCC pathway activity in a migraine model, highlighting the role of the S1P-S1PR1 pathway in activating and sensitizing dural trigeminovascular neurons associated with migraine. Further, S1PR1 emerges as a promising new target for migraine therapy."
Preclinical • CNS Disorders • Migraine • S1PR1
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A. SALINAS ABARCA1; M. ROMERO1; D. SALVEMINI2; S. AKERMAN3
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