A small molecule inhibitor of CD28 costimulation restrains pathogenic T-cell responses in inflammatory bowel disease. (PubMed, bioRxiv) - Oct 9, 2026 - "These findings support direct CD28 antagonism as a mechanistically differentiated alternative to B7-directed co-stimulation blockade for suppressing pathogenic T cell responses in preclinical models of IBD. A CD28-selective small molecule blocks pathogenic T cell activation and preserves Treg function unlike Abatacept in IBD models."
IO biomarker • Journal • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis • CD80 • CD86
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Moustafa Gabr; Saurabh Upadhyay; Shaoren Yuan; Sungwoo Cho
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