Towards Precision Medicine in Inflammatory Bowel Diseases: Pharmacogenetic Predictors of Ustekinumab Effectiveness and Persistence. (PubMed, Pharmaceuticals (Basel)) - Sep 27, 2026 - " This study provides real-world evidence supporting the effectiveness and persistence of ustekinumab in IBD patients. IL12B rs6887695 emerged as a potential pharmacogenetic marker associated with favorable ustekinumab outcomes; however, this exploratory and hypothesis-generating finding requires external validation in larger, independent cohorts before clinical application."
Biomarker • Journal • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis • HLA-C • IL12A • IL12B • PTPN2
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Anna Viola; Antonio Battaglia; Clara De Francesco; Claudia Ligresti; Giovanni Pallio; Michelangelo Rottura; Natasha Irrera; Vincenzo Arcoraci; Walter Fries; Ylenia Marino
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