Insulin Enhances Nitroglycerin-Induced Hyperalgesia Through Insulin-Responsive Receptor Signalling Involving the Trigeminovascular System and Meningeal Mast Cells. (PubMed, Eur J Neurosci) - Oct 9, 2026 - "The effects of hyperglycemia, insulin and the dual IR/IGF-1R inhibitor BMS-754807 were investigated. However, insulin facilitates migraine-related responses by enhancing trigeminal CGRP signalling and meningeal mast cell activation through IR and/or IGF-1R-related signalling. Modulation of insulin-responsive IR/IGF-1R-related signalling within the trigeminovascular system may represent a potential target for future therapeutic strategies."
Journal • CNS Disorders • Diabetes • Inflammation • Metabolic Disorders • Migraine • Pain • FOS • IR
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Erkan Kilinc; Humeyra Celik; Ibrahim Ethem Torun; Muhammet Guzel Kurtoglu
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