Irreversible paraplegia due to transverse myelitis as a rare complication of CAR T-cell therapy in a patient with B-cell lymphoma. (PubMed, Postep Psychiatr Neurol) - Oct 21, 2026 - "A 45-year-old woman with primary mediastinal B-cell lymphoma received axicabtagene ciloleucel...Despite treatment with corticosteroids, anakinra, and intravenous immunoglobulin, no neurological improvement was observed...This case highlights a rare and severe form of CAR T-cell-related neurotoxicity, manifesting as transverse myelitis in the absence of a marked inflammatory response. The refractory course and lack of standard treatment options underscore the need for greater awareness, reporting, and further research into atypical neurological complications of CAR T-cell therapy."
Journal • B Cell Lymphoma • CNS Disorders • Epilepsy • Hematological Malignancies • Lymphoma • Mediastinal B Cell Lymphoma • Non-Hodgkin's Lymphoma • Oncology • Primary Mediastinal Large B-Cell Lymphoma
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Adam A Niezgoda; Anna Lojko-Dankowska; Anna Wache; Lidia A Gil; Micha? Macha?a; Tomasz Dynowski
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