Biopsy-proven inflammatory pulmonary opacities mimicking lymphoma relapse after CD19 CAR-T-cell therapy. (PubMed, J Clin Exp Hematop) - Oct 1, 2026 - "We report a patient with refractory diffuse large B-cell lymphoma who developed newly apparent or re-enlarged FDG-avid pulmonary opacities four months after axicabtagene ciloleucel infusion...This case illustrates that organizing pneumonia-like inflammatory lesions may arise at prior lymphoma-suspected pulmonary sites after CAR-T-cell therapy and closely mimic pulmonary relapse on FDG-PET/CT. When new FDG-avid pulmonary lesions arise after CAR-T-cell therapy, particularly at prior lymphoma sites, tissue confirmation is essential to avoid misdiagnosis and unnecessary treatment escalation."
IO biomarker • Journal • B Cell Lymphoma • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Infectious Disease • Lymphoma • Non-Hodgkin's Lymphoma • Oncology • Pneumonia • Respiratory Diseases
|
|
Haruto Nishida; Kazuki Okuhiro; Kuniko Takano; Manami Iwanaga; Masao Ogata; Oju Katayama; Shuhei Honda; Takami Haruyama; Takumi Nishikawa; Yosuke Kodama; Yui Moroga
|