Lipid Activation of a Thalamic GPCR Extends Working Memory Time-scales. (PubMed, bioRxiv) - Oct 2, 2026 - "Cell-based assays confirmed that the endogenous cannabinoid anandamide (AEA), but not other closely related family members or derivatives, robustly activates Gpr12...Thus, while cannabinoids often impair memory, here we identify an AEA-Gpr12 signaling axis in thalamus that enhances memory, including in primates. These findings identify a lipidic signaling mechanism in thalamus that is sufficient to control and extend working memory duration."
Journal
|
|
Alessandra Bonito-Oliva; Amy F T Arnsten; Andrew Luskin; Celine Chen; Genelle Rankin; James Newton Brandt; John Fak; Leslie J Sibener; Miriam Kirylo; Navid Paknejad; Priya Rajasethupathy; Vanessa Ruta
|