Morphine causes distinct changes in the lipidome throughout the brain and body after acute or chronic administration: implications for novel endogenous lipid signaling systems involved in opioid reward and withdrawal. (PubMed, bioRxiv) - Oct 2, 2026 - "Many of these studies are focused on the endocannabinoid (eCB) system, and its primary eCB ligands, Anandamide (AEA) and 2-arachidonoylglycerol (2-AG). Levels of AEA and 2-AG were largely unchanged; however, levels of the N -acyl GABAs, N -acyl valines, N -acyl taurines, and specific bile acids ( e.g. DCA, TCA) showed the most dynamic changes by treatment group. These results provide information on novel endolipid signaling pathways that may contribute to the unwanted side effects of opioids, such as dependence and withdrawal, and provide novel avenues for the development of therapeutic strategies."
Journal • Addiction (Opioid and Alcohol) • Substance Abuse
|
|
Clarissa Schmitt; Elyse Chafee; Evan Cannon; Heather B Bradshaw; Ken Mackie; Taylor J Woodward
|