Crystallographic fragment screening discovers novel micromolar active inhibitors and druggable hotspots of SARS-CoV-2 PLpro.

antiviral therapeutics - Cyclica, Chinese Academy of Medical Sciences

http://www.ncbi.nlm.nih.gov/pubmed/41638277

Feng Yu; Huan Zhou; Jian Li; Li-Qing Huang; Minjun Li; Qi-Sheng Wang; Qin Xu; Shi-Hao Zheng; Tian-Liu Han; Wei-Wei Wang; Zhi-Min Zhu

Feb 5, 2026